PMDD vs Bipolar disorder: 5 Differences Patients Should Know

There are many differences between PMDD vs bipolar disorder that patients should know about.

Both PMDD (Premenstrual Dysphoric Disorder) and bipolar disorder are known for their mood swings and emotional ups and downs, but they stem from different causes and exhibit distinct patterns. While both can lead to feelings of irritability, depression, and fluctuating moods, it's crucial to grasp the key differences for proper diagnosis and treatment. In this blog, we’ll explore 5 important distinctions between PMDD and bipolar disorder to help you gain a clearer understanding of these conditions and how to manage them effectively.

PMDD vs Bipolar Disorder: 5 Differences To Know

What is PMDD vs Bipolar disorder?

PMDD, or Premenstrual Dysphoric Disorder, is a more intense version of premenstrual syndrome (PMS) that brings on severe mood swings, irritability, and a host of other physical and emotional symptoms in the week or two before menstruation. While many women experience PMS mildly, PMDD can really disrupt daily life, work, and relationships. The exact cause isn’t fully understood, but it’s thought to be linked to hormonal shifts during the menstrual cycle, with certain lifestyle choices or genetic factors possibly heightening the risk.

PMDD Symptoms  

Symptoms of PMDD are more severe than those of PMS and can include:

  • Mood swings  
  • Anger or irritability
  • Insomnia  
  • Anxiety and panic attacks
  • Depression and suicidal thoughts
  • Difficulty concentrating
  • Fatigue and low energy
  • Food cravings, binge eating or changes in appetite
  • Headaches
  • Feeling on edge, overwhelmed or tense

What is bipolar disorder?

Bipolar disorder, a complex and challenging mental health issue, significantly affects lives through its unpredictable mood swings. Also known as manic depression, this condition is marked by extreme shifts in mood, ranging from manic highs to depressive lows.

Symptoms of mania

Here are the most common symptoms of mania: 

  • Risky or out-of-control behavior
  • Feelings of elation or extreme irritability
  • A decreased need for sleep
  • Euphoria (a sense of well-being that exceeds reality or a feeling of invincibility
  • Talkativeness that seems out of character
  • Racing thoughts
  • Difficulty focusing
  • Poor decision making (spending sprees, reckless driving)

Symptoms of hypomania

Hypomania is marked by an elevated or irritable mood, along with a noticeable boost in energy and activity levels. Those going through hypomania often feel unusually cheerful, chatty, or self-assured, and their thoughts may race. They might find themselves engaging in impulsive or risky behaviors, such as splurging on shopping sprees or making hasty decisions, all while feeling little to no need for sleep. 

Although hypomania isn't as intense as full-blown mania, it can still throw a wrench in daily life, lead to questionable judgment, and create issues in relationships or at work. It's frequently a significant aspect of Bipolar 2 disorder.

Symptoms of depression

Depressive episode symptoms include:

  • Prolonged low mood, encompassing sadness, hopelessness, or a sense of emptiness
  • Lowered energy levels and feeling physically drained
  • Sleep disturbances, either too little or too much
  • Challenges with concentration and decision-making
  • Problems with memory
  • Appetite changes
  • Reduced interest or enjoyment in previously liked activities
  • Suicidal thoughts or a negative self-view

Additionally, mixed episodes are possible, where symptoms of both manic and depressive episodes occur at the same time.

5 Differences Between PMDD vs Bipolar Disorder

1. Timing and Cyclic Pattern in PMDD vs Bipolar Disorder

The timing and cyclic pattern of mood changes differ significantly between PMDD vs bipolar:

  • PMDD:
    • Symptoms are tied to the menstrual cycle, appearing 7-10 days before menstruation.
    • Symptoms resolve once menstruation begins.
    • Highly predictable, with symptoms recurring monthly.
  • Bipolar disorder:
    • Mood episodes (manic or depressive) can occur at any time.
    • Not linked to the menstrual cycle, making episodes unpredictable.
    • Can happen randomly, without a clear cyclic pattern.

2. Type of Mood Changes in PMDD vs Bipolar Disorder

PMDD vs bipolar also differs in the type of mood changes experienced. PMDD is primarily characterized by severe irritability, mood swings, anxiety, and depression that occur before menstruation. These mood changes are often coupled with physical symptoms such as fatigue, sleep disturbances, and physical discomfort. 

On the other hand, bipolar disorder includes more extreme mood shifts, including hypomania (in Bipolar 2) or full-blown mania (in Bipolar 1), in addition to depression. These manic episodes are marked by elevated or unusually irritable mood, increased energy, impulsive behavior, and risky activities.

PMDD vs bipolar:

  • PMDD focuses more on premenstrual irritability and depression, while bipolar disorder involves more extreme shifts between mania and depression.
  • Bipolar PMDD would involve both conditions coexisting, with more severe mood swings and a mix of manic and depressive symptoms

3. Duration of Episodes

The duration of episodes is a key difference between PMDD vs bipolar. PMDD symptoms last for a short, predictable period — usually only the 7-10 days leading up to menstruation — and typically resolve once the period begins. This clear timeline of symptoms allows for a more straightforward diagnosis of PMDD.

In contrast, bipolar disorder is marked by mood episodes that can last much longer, often weeks or even months. These episodes can occur without any seasonal or cyclical pattern, making them harder to track or anticipate compared to PMDD vs bipolar.

The duration of episodes in each disorder is a key distinguishing factor:

  • PMDD:
    • Episodes last 7-10 days leading up to menstruation.
    • Symptoms typically disappear with the start of the menstrual period.
    • Limited in duration, generally predictable each month.
  • Bipolar disorder:
    • Episodes last from weeks to months.
    • Can involve longer manic or depressive phases, independent of any external cycle.
    • Episodes can occur randomly without a clear start or end.

PMDD vs bipolar:

  • PMDD episodes are short-lived and cyclical, while bipolar episodes are long-lasting and can occur unpredictably.
  • Bipolar disorder tends to have a longer duration, requiring more intensive management.

4. Underlying Cause

The underlying causes of PMDD and bipolar are quite distinct. PMDD vs bipolar in terms of origins: PMDD is largely believed to be hormonally driven, with fluctuations in estrogen and progesterone levels during the luteal phase of the menstrual cycle playing a major role in symptom development. Genetics, stress, and nutritional factors may also contribute to PMDD, but its primary cause is related to hormonal changes.

 In contrast, bipolar disorder is a chronic mood disorder believed to have a strong genetic component, and its causes are thought to involve both genetic predisposition and abnormalities in brain chemistry, particularly neurotransmitters like serotonin and dopamine.

5. Treatment Approaches

The treatment approaches for PMDD and bipolar disorder differ significantly:

Treatment ApproachPMDDBipolar Disorder
Medications- Hormonal therapies (birth control, hormone replacement therapy)- Mood stabilizers (e.g., lithium, anticonvulsants)
- SSRIs (selective serotonin reuptake inhibitors) for mood symptoms- Atypical antipsychotics for mood regulation
- Diuretics or NSAIDs for physical symptoms (headaches, fatigue, cramps)- Antidepressants (used cautiously to avoid triggering mania)
Psychotherapy- Cognitive-behavioral therapy (CBT) to manage mood swings and stress- Cognitive-behavioral therapy (CBT) for managing mood cycles and improving coping
Lifestyle Changes- Regular exercise, improved sleep, and stress management- Regular routine, sleep hygiene, and stress management are critical for mood stability
Diet and Supplements- Calcium, magnesium, and vitamin B6 supplements may help reduce symptoms- Omega-3 fatty acids, certain vitamins may support overall mental health
Monitoring- Tracking menstrual cycle and symptoms to anticipate episodes- Continuous monitoring of mood swings to adjust treatment

Can I have both PMDD and bipolar disorder?

Yes, it is possible to have both PMDD and bipolar disorder at the same time. This situation is referred to as comorbidity, where two or more disorders coexist. Interestingly, some individuals with bipolar disorder might find that their mood swings and depressive episodes become more intense in relation to their menstrual cycle, which can resemble PMDD. The symptoms of PMDD and bipolar disorder, like irritability, mood swings, and depression, can overlap, making it tricky to diagnose. 

The main distinction, however, is in the timing—PMDD is linked to the menstrual cycle, while bipolar disorder features mood episodes that can happen at any time and last beyond the cycle. If you find yourself dealing with both conditions, managing them can be quite a challenge and often requires a thoughtful treatment approach. This might include a mix of hormonal therapies, mood stabilizers, and psychotherapy. If you think you might have both PMDD and bipolar disorder, it’s really important to get a professional evaluation to ensure you receive an accurate diagnosis and a suitable treatment plan.

Do I have PMDD or bipolar disorder?

Figuring out whether you have PMDD or bipolar disorder takes a thoughtful look at your symptoms, their timing, and how long your mood changes last. PMDD is closely tied to your menstrual cycle, with symptoms like irritability, mood swings, and depression popping up about 7-10 days before your period and easing off once it starts. In contrast, bipolar disorder is characterized by more prolonged mood changes, featuring episodes of mania or hypomania (think elevated mood, impulsivity, and lots of energy) followed by depressive phases, and these shifts can happen regardless of your menstrual cycle. 

To tell PMDD apart from bipolar disorder, think about whether your mood symptoms follow a predictable pattern around your period or if they seem random and last longer than the usual 7-10 days associated with PMDD. If your mood swings are intense and occur outside of your menstrual cycle, it might be a sign of bipolar disorder. But remember, only a healthcare professional can give you a proper diagnosis, and often, they’ll need to observe and test further to get a clear picture.

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FAQs about PMDD vs bipolar disorder

Is PMDD like bipolar?

PMDD and bipolar disorder both involve mood swings, but they are different. PMDD is linked to the menstrual cycle and causes mood changes that occur just before menstruation, while bipolar disorder involves long-term mood episodes of depression and mania/hypomania that happen independently of the menstrual cycle. Although they share some symptoms, their causes and patterns are distinct.


What about PMDD vs Bipolar 2?
Bipolar vs PMDD involves understanding the key differences: Bipolar disorder, including Bipolar 2, is characterized by long-term mood swings vs bipolar involving hypomania and depression, while PMDD involves extreme mood swings triggered by hormonal fluctuations, particularly before menstruation. In PMDD vs bipolar, PMDD’s symptoms resolve after menstruation starts, but bipolar PMDD may result in ongoing mood issues, independent of the menstrual cycle.

Is PMDD similar to bipolar?
PMDD or bipolar can both present with irritability, mood swings, and depression, but the mood swings in PMDD are linked directly to the menstrual cycle, while bipolar disorder or PMDD is characterized by long-term mood disorders that can occur at any time, regardless of menstrual timing. PMDD vs bipolar, the main difference is that bipolar includes both manic and depressive episodes, while PMDD typically only involves severe depression and irritability before menstruation.

How often does PMDD occur?
PMDD occurs monthly, typically in the 7-10 days before menstruation begins. It is a cyclical condition, so the symptoms usually appear during the luteal phase of the menstrual cycle and subside once menstruation starts. If untreated, PMDD can persist for years or until menopause.

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